![]() ![]() The potential clinical and therapeutic roles of DHEA/DHEAS have been studied extensively, but the data remain controversial and largely inconclusive. Some authors have linked obesity in childhood with early adrenarche, i.e., increased circulating levels of adrenal androgens others have associated low levels in late life with increased frailty and all-cause mortality. During the last decades, several epidemiologic and cohort studies have shown the age-related circulating levels of DHEA/DHEAS these first increase in childhood, a process called “adrenarche”, peak in the 3 rd decade of life, and progressively decrease in midlife, a phenomenon called “adrenopause”. They are both precursor hormones that may be transformed into weak androgens or estrogens. ![]() Dehydroepiandrosterone (DHEA) and its metabolite DHEA sulfate (DHEAS), are steroid pre-hormones synthesized and secreted primarily by the zona reticularis of the adrenal cortex in response to adrenocorticotropic hormone (ACTH).
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